7MYP

Crystal Structure of HIV-1 PRS17 with GRL-44-10A

Summary for 7MYP

Entry DOI	10.2210/pdb7myp/pdb
Descriptor	Protease, GLYCEROL, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	hiv-1 protease, multi drug resistant, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22433.08
Authors	Agniswamy, J.,Weber, I.T. (deposition date: 2021-05-21, release date: 2021-07-28, Last modification date: 2023-10-18)
Primary citation	Agniswamy, J.,Kneller, D.W.,Ghosh, A.K.,Weber, I.T. Novel HIV PR inhibitors with C4-substituted bis-THF and bis-fluoro-benzyl target the two active site mutations of highly drug resistant mutant PR S17 . Biochem.Biophys.Res.Commun., 566:30-35, 2021 Cited by PubMed: 34111669 DOI: 10.1016/j.bbrc.2021.05.094 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation