7MYA

Structure of proline utilization A with the FAD covalently-modified by 1,3-dithiolane

Summary for 7MYA

Entry DOI	10.2210/pdb7mya/pdb
Descriptor	Bifunctional protein PutA, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[5-(1,3-dithiolan-2-yl)-7,8-dimethyl-2,4-dioxo-1,3,4,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate, MAGNESIUM ION, ... (9 entities in total)
Functional Keywords	flavoenzyme, rossmann fold, proline dehydrognease, aldehyde dehydrogenase, proline catabolism, substrate channeling, bifunctional enzyme, oxidoreductase
Biological source	Sinorhizobium meliloti SM11
Total number of polymer chains	2
Total formula weight	268868.01
Authors	Tanner, J.J.,Campbell, A.C. (deposition date: 2021-05-20, release date: 2021-09-29, Last modification date: 2023-10-18)
Primary citation	Campbell, A.C.,Prater, A.R.,Bogner, A.N.,Quinn, T.P.,Gates, K.S.,Becker, D.F.,Tanner, J.J. Photoinduced Covalent Irreversible Inactivation of Proline Dehydrogenase by S-Heterocycles. Acs Chem.Biol., 16:2268-2279, 2021 Cited by PubMed: 34542291 DOI: 10.1021/acschembio.1c00427 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.56 Å)

Structure validation