7MXL

Complex of Bet v 1 with the Fab fragments of a three antibody cocktail

Summary for 7MXL

Entry DOI	10.2210/pdb7mxl/pdb
EMDB information	24073
Descriptor	REGN5713 antibody Fab fragment heavy chain, REGN5713 antibody Fab fragment light chain, Major pollen allergen Bet v 1-A, ... (7 entities in total)
Functional Keywords	complex, antibody, birch pollen allergen bet v 1, allergen
Biological source	Homo sapiens More
Total number of polymer chains	7
Total formula weight	159713.83
Authors	Romero-Hernandez, A.,Franklin, M.C. (deposition date: 2021-05-19, release date: 2021-07-21, Last modification date: 2024-11-20)
Primary citation	Atanasio, A.,Franklin, M.C.,Kamat, V.,Hernandez, A.R.,Badithe, A.,Ben, L.H.,Jones, J.,Bautista, J.,Yancopoulos, G.D.,Olson, W.,Murphy, A.J.,Sleeman, M.A.,Orengo, J.M. Targeting immunodominant Bet v 1 epitopes with monoclonal antibodies prevents the birch allergic response. J.Allergy Clin.Immunol., 149:200-211, 2022 Cited by PubMed Abstract: Blocking the major cat allergen, Fel d 1, with mAbs was effective in preventing an acute cat allergic response. PubMed: 34126155 DOI: 10.1016/j.jaci.2021.05.038 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation