7MX3

Crystal structure of human RIPK3 complexed with GSK'843

7MX3 の概要

• エントリーDOI: 10.2210/pdb7mx3/pdb
• 分子名称: Receptor-interacting serine/threonine-protein kinase 3, 3-(1,3-benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: kinase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 141932.01

構造登録者

Davies, K.A.,Czabotar, P.E. (登録日: 2021-05-18, 公開日: 2021-11-24, 最終更新日: 2024-04-03)

• 主引用文献: Meng, Y.,Davies, K.A.,Fitzgibbon, C.,Young, S.N.,Garnish, S.E.,Horne, C.R.,Luo, C.,Garnier, J.M.,Liang, L.Y.,Cowan, A.D.,Samson, A.L.,Lessene, G.,Sandow, J.J.,Czabotar, P.E.,Murphy, J.M.; Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.; Nat Commun, 12:6783-6783, 2021; PubMed: 34811356; DOI: 10.1038/s41467-021-27032-x

実験手法

X-RAY DIFFRACTION (3.23 Å)