7MX1

PLK-1 polo-box domain in complex with a high affinity macrocycle synthesized using a novel glutamic acid analog

7MX1 の概要

• エントリーDOI: 10.2210/pdb7mx1/pdb
• 分子名称: Serine/threonine-protein kinase PLK1, ACE-PRO-LEU-ALA-SER-TPO, N-[(4S)-4,5-diamino-5-oxopentyl]-10-phenyldecanamide, ... (4 entities in total)
• 機能のキーワード: macrocyclic phosphopeptide, mitotic kinase. polo-box domain, protein binding
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 56480.49

構造登録者

Grant, R.A.,Hymel, D.,Yaffe, M.B.,Burke, T.R. (登録日: 2021-05-17, 公開日: 2022-03-30, 最終更新日: 2023-10-18)

• 主引用文献: Hymel, D.,Tsuji, K.,Grant, R.A.,Chingle, R.M.,Kunciw, D.L.,Yaffe, M.B.,Burke Jr., T.R.; Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain - binding peptide macrocycles.; Org.Biomol.Chem., 19:7843-7854, 2021; PubMed: 34346472; DOI: 10.1039/d1ob01120k

実験手法

X-RAY DIFFRACTION (1.64 Å)