7MU7

Ask1 bound to compound 3

Summary for 7MU7

• Entry DOI: 10.2210/pdb7mu7/pdb
• Descriptor: Mitogen-activated protein kinase kinase kinase 5, DIMETHYL SULFOXIDE, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: ask1, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 76112.07

Authors

Chodaparambil, J.V.,Marcotte, D.J. (deposition date: 2021-05-14, release date: 2022-05-18, Last modification date: 2023-10-18)

• Primary citation: Chodaparambil, J.V.; Discovery of Potent, Selective and CNS-Penetrant Apoptosis Signal-regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation in Vivo; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.298 Å)