7MT5

Crystal structure of tryptophan synthase in complex with F9, Cs+, pH7.8 - alpha aminoacrylate form - E(A-A)

Summary for 7MT5

Entry DOI	10.2210/pdb7mt5/pdb
Descriptor	Tryptophan synthase alpha chain, Tryptophan synthase beta chain, 2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE, ... (6 entities in total)
Functional Keywords	plp-dependent enzyme tryptophan synthase, lyase, lyase-inhibitor complex, lyase/inhibitor
Biological source	Salmonella typhimurium More
Total number of polymer chains	2
Total formula weight	72697.82
Authors	Drago, V.,Hilario, E.,Dunn, M.F.,Mueser, T.C.,Mueller, L.J. (deposition date: 2021-05-12, release date: 2021-12-29, Last modification date: 2023-10-18)
Primary citation	Holmes, J.B.,Liu, V.,Caulkins, B.G.,Hilario, E.,Ghosh, R.K.,Drago, V.N.,Young, R.P.,Romero, J.A.,Gill, A.D.,Bogie, P.M.,Paulino, J.,Wang, X.,Riviere, G.,Bosken, Y.K.,Struppe, J.,Hassan, A.,Guidoulianov, J.,Perrone, B.,Mentink-Vigier, F.,Chang, C.A.,Long, J.R.,Hooley, R.J.,Mueser, T.C.,Dunn, M.F.,Mueller, L.J. Imaging active site chemistry and protonation states: NMR crystallography of the tryptophan synthase alpha-aminoacrylate intermediate. Proc.Natl.Acad.Sci.USA, 119:-, 2022 Cited by PubMed: 34996869 DOI: 10.1073/pnas.2109235119 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation