7MQP
E. coli dihydrofolate reductase complexed with 4'-chloro-3'-(4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl)-[1,1'-biphenyl]-4-carboxamide (UCP1228)
Summary for 7MQP
Entry DOI | 10.2210/pdb7mqp/pdb |
Descriptor | Dihydrofolate reductase, 3'-[(2S)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-4'-methyl[1,1'-biphenyl]-4-carboxamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | inhibitor, antifolate, dhfr, oxidoreductase |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 19334.53 |
Authors | Lombardo, M.N.,Wright, D.L. (deposition date: 2021-05-06, release date: 2022-05-11, Last modification date: 2023-10-18) |
Primary citation | Krucinska, J.,Lombardo, M.N.,Erlandsen, H.,Estrada, A.,Si, D.,Viswanathan, K.,Wright, D.L. Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens. Commun Biol, 5:459-459, 2022 Cited by PubMed: 35562546DOI: 10.1038/s42003-022-03384-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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