7MQP

E. coli dihydrofolate reductase complexed with 4'-chloro-3'-(4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl)-[1,1'-biphenyl]-4-carboxamide (UCP1228)

Summary for 7MQP

• Entry DOI: 10.2210/pdb7mqp/pdb
• Descriptor: Dihydrofolate reductase, 3'-[(2S)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-4'-methyl[1,1'-biphenyl]-4-carboxamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: inhibitor, antifolate, dhfr, oxidoreductase
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 19334.53

Authors

Lombardo, M.N.,Wright, D.L. (deposition date: 2021-05-06, release date: 2022-05-11, Last modification date: 2023-10-18)

• Primary citation: Krucinska, J.,Lombardo, M.N.,Erlandsen, H.,Estrada, A.,Si, D.,Viswanathan, K.,Wright, D.L.; Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens.; Commun Biol, 5:459-459, 2022; PubMed: 35562546; DOI: 10.1038/s42003-022-03384-y

Experimental method

X-RAY DIFFRACTION (2.1 Å)