7MP5

Autoinhibited neurofibrobmin

Summary for 7MP5

Entry DOI	10.2210/pdb7mp5/pdb
EMDB information	23924 23929 23930
Descriptor	Isoform I of Neurofibromin (1 entity in total)
Functional Keywords	scaffold, ras-gap, heat repeat, autoinhibition, tumour suppressor, antitumor protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	636815.62
Authors	Lupton, C.J.,Bayly-Jones, C.,Ellisdon, A.M. (deposition date: 2021-05-04, release date: 2021-12-15, Last modification date: 2022-03-16)
Primary citation	Lupton, C.J.,Bayly-Jones, C.,D'Andrea, L.,Huang, C.,Schittenhelm, R.B.,Venugopal, H.,Whisstock, J.C.,Halls, M.L.,Ellisdon, A.M. The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1. Nat.Struct.Mol.Biol., 28:982-988, 2021 Cited by PubMed: 34887559 DOI: 10.1038/s41594-021-00687-2 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (5.6 Å)

Structure validation