7MOV
PTP1B 1-301 F225Y-R199N mutations
Summary for 7MOV
Entry DOI | 10.2210/pdb7mov/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 1, GLYCEROL, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | protein tyrosine phosphatase, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 72688.75 |
Authors | Torgeson, K.R.,Page, R.,Peti, W. (deposition date: 2021-05-03, release date: 2022-05-18, Last modification date: 2023-10-18) |
Primary citation | Torgeson, K.R.,Clarkson, M.W.,Granata, D.,Lindorff-Larsen, K.,Page, R.,Peti, W. Conserved conformational dynamics determine enzyme activity. Sci Adv, 8:eabo5546-eabo5546, 2022 Cited by PubMed: 35921420DOI: 10.1126/sciadv.abo5546 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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