7MON

Structure of human RIPK3-MLKL complex

7MON の概要

• エントリーDOI: 10.2210/pdb7mon/pdb
• 分子名称: Mixed lineage kinase domain-like protein, Receptor-interacting serine/threonine-protein kinase 3, N-[4-({2-[(cyclopropanecarbonyl)amino]pyridin-4-yl}oxy)-3-fluorophenyl]-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide, ... (4 entities in total)
• 機能のキーワード: pseudokinase, kinase, complex, necroptosis, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68806.46

構造登録者

Meng, Y.,Davies, K.A.,Czabotar, P.E.,Murphy, J.M. (登録日: 2021-05-03, 公開日: 2021-11-17, 最終更新日: 2023-10-18)

• 主引用文献: Meng, Y.,Davies, K.A.,Fitzgibbon, C.,Young, S.N.,Garnish, S.E.,Horne, C.R.,Luo, C.,Garnier, J.M.,Liang, L.Y.,Cowan, A.D.,Samson, A.L.,Lessene, G.,Sandow, J.J.,Czabotar, P.E.,Murphy, J.M.; Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.; Nat Commun, 12:6783-6783, 2021; PubMed: 34811356; DOI: 10.1038/s41467-021-27032-x

実験手法

X-RAY DIFFRACTION (2.23 Å)