7MJS

Single-Particle Cryo-EM Structure of Major Facilitator Superfamily Domain containing 2A in complex with LPC-18:3

7MJS の概要

• エントリーDOI: 10.2210/pdb7mjs/pdb
• EMDBエントリー: 23883
• 分子名称: 2AG3 Fab heavy chain, 2AG3 Fab light chain, Major Facilitator Superfamily Domain containing 2A, ... (5 entities in total)
• 機能のキーワード: mfs transporters, lysolipids, blood-brain barrier, omega-3 fatty acids, lipid transport-immune system complex, lipid transport/immune system
• 由来する生物種: Synthetic construct; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 111051.95

構造登録者

Cater, R.J.,Chua, G.L.,Erramilli, S.K.,Keener, J.E.,Choy, B.C.,Tokarz, P.,Chin, C.F.,Quek, D.Q.Y.,Kloss, B.,Pepe, J.G.,Parisi, G.,Wong, B.H.,Clarke, O.B.,Marty, M.T.,Kossiakoff, A.A.,Khelashvili, G.,Silver, D.L.,Mancia, F. (登録日: 2021-04-20, 公開日: 2021-06-16, 最終更新日: 2021-07-28)

• 主引用文献: Cater, R.J.,Chua, G.L.,Erramilli, S.K.,Keener, J.E.,Choy, B.C.,Tokarz, P.,Chin, C.F.,Quek, D.Q.Y.,Kloss, B.,Pepe, J.G.,Parisi, G.,Wong, B.H.,Clarke, O.B.,Marty, M.T.,Kossiakoff, A.A.,Khelashvili, G.,Silver, D.L.,Mancia, F.; Structural basis of omega-3 fatty acid transport across the blood-brain barrier.; Nature, 595:315-319, 2021; PubMed: 34135507; DOI: 10.1038/s41586-021-03650-9

実験手法

ELECTRON MICROSCOPY (3.03 Å)