7MES

Structure of ALDH4A1 complexed with trans-4-Hydroxy-D-proline

Summary for 7MES

Entry DOI	10.2210/pdb7mes/pdb
Descriptor	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (4S)-4-hydroxy-D-proline, ... (8 entities in total)
Functional Keywords	aldehyde dehydrogenase, rossmann fold, nucleotide binding, acting on aldehyde or oxo group of donors, nad or nadp as acceptor, mitochondria, oxidoreductase
Biological source	Mus musculus (Mouse)
Total number of polymer chains	2
Total formula weight	126899.11
Authors	Bogner, A.N.,Stiers, K.M.,Tanner, J.J. (deposition date: 2021-04-07, release date: 2021-06-09, Last modification date: 2023-10-18)
Primary citation	Bogner, A.N.,Stiers, K.M.,McKay, C.M.,Becker, D.F.,Tanner, J.J. Structural basis for the stereospecific inhibition of the dual proline/hydroxyproline catabolic enzyme ALDH4A1 by trans-4-hydroxy-L-proline. Protein Sci., 30:1714-1722, 2021 Cited by PubMed: 34048122 DOI: 10.1002/pro.4131 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.37 Å)

Structure validation