7MES

Structure of ALDH4A1 complexed with trans-4-Hydroxy-D-proline

7MES の概要

• エントリーDOI: 10.2210/pdb7mes/pdb
• 分子名称: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (4S)-4-hydroxy-D-proline, ... (8 entities in total)
• 機能のキーワード: aldehyde dehydrogenase, rossmann fold, nucleotide binding, acting on aldehyde or oxo group of donors, nad or nadp as acceptor, mitochondria, oxidoreductase
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 126899.11

構造登録者

Bogner, A.N.,Stiers, K.M.,Tanner, J.J. (登録日: 2021-04-07, 公開日: 2021-06-09, 最終更新日: 2023-10-18)

• 主引用文献: Bogner, A.N.,Stiers, K.M.,McKay, C.M.,Becker, D.F.,Tanner, J.J.; Structural basis for the stereospecific inhibition of the dual proline/hydroxyproline catabolic enzyme ALDH4A1 by trans-4-hydroxy-L-proline.; Protein Sci., 30:1714-1722, 2021; PubMed: 34048122; DOI: 10.1002/pro.4131

実験手法

X-RAY DIFFRACTION (1.37 Å)