7ME5

Structure of the extracellular WNT-binding module in Drl-2

7ME5 の概要

• エントリーDOI: 10.2210/pdb7me5/pdb
• 関連するPDBエントリー: 7ME4
• 分子名称: Tyrosine-protein kinase transmembrane receptor DRL-2, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: wnt signaling, receptor tyrosine kinases, acylation, growth factor signaling, co-receptor, pseudokinases, ligand, receptor, cancer, signaling protein
• 由来する生物種: Drosophila melanogaster (Fruit fly)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18286.83

構造登録者

Shi, F.,Mendrola, J.M.,Perry, K.,Stayrook, S.E.,Lemmon, M.A. (登録日: 2021-04-06, 公開日: 2021-10-13, 最終更新日: 2024-10-09)

• 主引用文献: Shi, F.,Mendrola, J.M.,Sheetz, J.B.,Wu, N.,Sommer, A.,Speer, K.F.,Noordermeer, J.N.,Kan, Z.Y.,Perry, K.,Englander, S.W.,Stayrook, S.E.,Fradkin, L.G.,Lemmon, M.A.; ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes.; Cell Rep, 37:109834-109834, 2021; PubMed: 34686333; DOI: 10.1016/j.celrep.2021.109834

実験手法

X-RAY DIFFRACTION (2 Å)