7MD8
Crystal structure of Staphylococcus aureus cystathionine gamma lyase holoenzyme Y103N mutant co-crystallized with NL2
Summary for 7MD8
Entry DOI | 10.2210/pdb7md8/pdb |
Descriptor | Bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase, PYRIDOXAL-5'-PHOSPHATE, SODIUM ION, ... (6 entities in total) |
Functional Keywords | amino-acid biosynthesis, cysteine biosynthesis, hydrogen sulfide production, plp dependent enzyme, lyase |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 1 |
Total formula weight | 42452.54 |
Authors | Nuthanakanti, A.,Serganov, A.,Kaushik, A. (deposition date: 2021-04-03, release date: 2021-06-23, Last modification date: 2023-11-15) |
Primary citation | Shatalin, K.,Nuthanakanti, A.,Kaushik, A.,Shishov, D.,Peselis, A.,Shamovsky, I.,Pani, B.,Lechpammer, M.,Vasilyev, N.,Shatalina, E.,Rebatchouk, D.,Mironov, A.,Fedichev, P.,Serganov, A.,Nudler, E. Inhibitors of bacterial H 2 S biogenesis targeting antibiotic resistance and tolerance. Science, 372:1169-1175, 2021 Cited by PubMed: 34112687DOI: 10.1126/science.abd8377 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.06 Å) |
Structure validation
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