7MAR
Drug Resistant HIV-1 Protease (L10F, M46I, I47V, I50V, F53L, L63P, I72V, G73S, V82I, I85V) in Complex with DRV
Summary for 7MAR
Entry DOI | 10.2210/pdb7mar/pdb |
Descriptor | Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE (3 entities in total) |
Functional Keywords | drug resistance, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus type 1 group M subtype B (HIV-1) |
Total number of polymer chains | 4 |
Total formula weight | 44238.12 |
Authors | Lockbaum, G.J.,Schiffer, C.A. (deposition date: 2021-03-31, release date: 2022-11-09, Last modification date: 2023-10-18) |
Primary citation | Lockbaum, G.J.,Schiffer, C.A. Drug Resistant HIV-1 Protease (L10F, M46I, I47V, I50V, F53L, L63P, I72V, G73S, V82I, I85V) in Complex with DRV To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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