7M5V

human ATP13A2 in the AMPPNP-bound occluded state

Summary for 7M5V

Entry DOI	10.2210/pdb7m5v/pdb
EMDB information	23683
Descriptor	Polyamine-transporting ATPase 13A2, (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, MAGNESIUM ION, ... (11 entities in total)
Functional Keywords	ion transport occluded state, membrane protein, transport protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	136142.28
Authors	Lee, K.P.K. (deposition date: 2021-03-24, release date: 2022-03-30, Last modification date: 2022-04-27)
Primary citation	Tillinghast, J.,Drury, S.,Bowser, D.,Benn, A.,Lee, K.P.K. Structural mechanisms for gating and ion selectivity of the human polyamine transporter ATP13A2. Mol.Cell, 81:4650-4662.e4, 2021 Cited by PubMed: 34715014 DOI: 10.1016/j.molcel.2021.10.002 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.9 Å)

Structure validation