7M5U

Crystal structure of human MPP8 chromodomain in complex with peptidomimetic ligand UNC5246

Summary for 7M5U

• Entry DOI: 10.2210/pdb7m5u/pdb
• Descriptor: M-phase phosphoprotein 8, UNC5246 (3 entities in total)
• Functional Keywords: chromodomain, peptidomimetic, chromatin, gene regulation
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 8138.34

Authors

Budziszewski, G.R.,McGinty, R.K.,Waybright, J.M.,Norris, J.L.,James, L.I. (deposition date: 2021-03-24, release date: 2021-09-01, Last modification date: 2023-11-15)

• Primary citation: Waybright, J.M.,Clinkscales, S.E.,Barnash, K.D.,Budziszewski, G.R.,Rectenwald, J.M.,Chiarella, A.M.,Norris-Drouin, J.L.,Cholensky, S.H.,Pearce, K.H.,Herring, L.E.,McGinty, R.K.,Hathaway, N.A.,James, L.I.; A Peptidomimetic Ligand Targeting the Chromodomain of MPP8 Reveals HRP2's Association with the HUSH Complex.; Acs Chem.Biol., 16:1721-1736, 2021; PubMed: 34415726; DOI: 10.1021/acschembio.1c00429

Experimental method

X-RAY DIFFRACTION (2.02 Å)