7M5U
Crystal structure of human MPP8 chromodomain in complex with peptidomimetic ligand UNC5246
Summary for 7M5U
Entry DOI | 10.2210/pdb7m5u/pdb |
Descriptor | M-phase phosphoprotein 8, UNC5246 (3 entities in total) |
Functional Keywords | chromodomain, peptidomimetic, chromatin, gene regulation |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 8138.34 |
Authors | Budziszewski, G.R.,McGinty, R.K.,Waybright, J.M.,Norris, J.L.,James, L.I. (deposition date: 2021-03-24, release date: 2021-09-01, Last modification date: 2023-11-15) |
Primary citation | Waybright, J.M.,Clinkscales, S.E.,Barnash, K.D.,Budziszewski, G.R.,Rectenwald, J.M.,Chiarella, A.M.,Norris-Drouin, J.L.,Cholensky, S.H.,Pearce, K.H.,Herring, L.E.,McGinty, R.K.,Hathaway, N.A.,James, L.I. A Peptidomimetic Ligand Targeting the Chromodomain of MPP8 Reveals HRP2's Association with the HUSH Complex. Acs Chem.Biol., 16:1721-1736, 2021 Cited by PubMed: 34415726DOI: 10.1021/acschembio.1c00429 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.02 Å) |
Structure validation
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