7M5U

Crystal structure of human MPP8 chromodomain in complex with peptidomimetic ligand UNC5246

7M5U の概要

• エントリーDOI: 10.2210/pdb7m5u/pdb
• 分子名称: M-phase phosphoprotein 8, UNC5246 (3 entities in total)
• 機能のキーワード: chromodomain, peptidomimetic, chromatin, gene regulation
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 8138.34

構造登録者

Budziszewski, G.R.,McGinty, R.K.,Waybright, J.M.,Norris, J.L.,James, L.I. (登録日: 2021-03-24, 公開日: 2021-09-01, 最終更新日: 2023-11-15)

• 主引用文献: Waybright, J.M.,Clinkscales, S.E.,Barnash, K.D.,Budziszewski, G.R.,Rectenwald, J.M.,Chiarella, A.M.,Norris-Drouin, J.L.,Cholensky, S.H.,Pearce, K.H.,Herring, L.E.,McGinty, R.K.,Hathaway, N.A.,James, L.I.; A Peptidomimetic Ligand Targeting the Chromodomain of MPP8 Reveals HRP2's Association with the HUSH Complex.; Acs Chem.Biol., 16:1721-1736, 2021; PubMed: 34415726; DOI: 10.1021/acschembio.1c00429

実験手法

X-RAY DIFFRACTION (2.02 Å)