7M2L
The internal aldimine form of the wild-type Salmonella Typhimurium Tryptophan Synthase in complex with N-(4'-trifluoromethoxybenzoyl)-2-amino-1-ethylphosphate (F6F) inhibitor at the alpha-and beta-site, sodium ion at the metal coordination site, and another F6F molecule at the enzyme beta-site at 1.60 Angstrom resolution. Two of the beta-Q114 rotamer conformations allows a hydrogen bond to form with the PLP oxygen at the position 3 in the ring
7M2L の概要
エントリーDOI | 10.2210/pdb7m2l/pdb |
関連するPDBエントリー | 4KKX 4WX2 4Y6G 4ZQC 5BW6 7KU9 |
分子名称 | Tryptophan synthase alpha chain, Tryptophan synthase beta chain, 2-{[4-(TRIFLUOROMETHOXY)BENZOYL]AMINO}ETHYL DIHYDROGEN PHOSPHATE, ... (10 entities in total) |
機能のキーワード | inhibitor, internal aldimine, lyase, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
由来する生物種 | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 詳細 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 73250.96 |
構造登録者 | |
主引用文献 | Hilario, E.,Dunn, M.F.,Mueller, L.J. The internal aldimine form of the wild-type Salmonella Typhimurium Tryptophan Synthase in complex with N-(4'-trifluoromethoxybenzoyl)-2-amino-1-ethylphosphate (F6F) inhibitor at the alpha-and beta-site, sodium ion at the metal coordination site, and another F6F molecule at the enzyme beta-site at 1.60 Angstrom resolution. To be Published, |
実験手法 |
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