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7M20

18-mer HeLa-tubulin rings in complex with Cryptophycin 1

Summary for 7M20
Entry DOI10.2210/pdb7m20/pdb
Related7LXB 7M18
EMDB information23569 23615 23627
DescriptorTubulin beta-3 chain, Tubulin alpha-1B chain, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywordsanti-tumor, microtubule, tubulin-rings, polymerization-inhibitor, cell cycle
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains18
Total formula weight920767.72
Authors
Eren, E. (deposition date: 2021-03-15, release date: 2021-09-08, Last modification date: 2024-05-29)
Primary citationEren, E.,Watts, N.R.,Sackett, D.L.,Wingfield, P.T.
Conformational changes in tubulin upon binding cryptophycin-52 reveal its mechanism of action.
J.Biol.Chem., 297:101138-101138, 2021
Cited by
PubMed: 34461087
DOI: 10.1016/j.jbc.2021.101138
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (3.84 Å)
Structure validation

223532

건을2024-08-07부터공개중

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