7M1Z

Targeting Enterococcus faecalis HMG-CoA reductase with a novel non-statin inhibitor

7M1Z の概要

• エントリーDOI: 10.2210/pdb7m1z/pdb
• 分子名称: Hydroxymethylglutaryl-CoA reductase, degradative, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL, ... (8 entities in total)
• 機能のキーワード: ligands, metabolism, drug target, hmg-coa, mevalonate, prokaryote., antibiotic
• 由来する生物種: Enterococcus faecalis (Streptococcus faecalis)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 192901.73

構造登録者

Bose, S.,Steussy, C.N.,Stauffacher, C.V. (登録日: 2021-03-15, 公開日: 2022-09-21, 最終更新日: 2023-10-25)

• 主引用文献: Bose, S.,Steussy, C.N.,Lopez-Perez, D.,Schmidt, T.,Kulathunga, S.C.,Seleem, M.N.,Lipton, M.,Mesecar, A.D.,Rodwell, V.W.,Stauffacher, C.V.; Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor; Nat Commun, 2023; DOI: 10.1038/s42003-023-04639-y

実験手法

X-RAY DIFFRACTION (2.27 Å)