7LZS

Crystal structure of the BCL6 BTB domain in complex with OICR-11029

Summary for 7LZS

• Entry DOI: 10.2210/pdb7lzs/pdb
• Descriptor: B-cell lymphoma 6 protein, 3-chloro-5-{7-[2-({5-chloro-2-[(3S)-3-methylmorpholin-4-yl]pyridin-4-yl}amino)-2-oxoethyl]-3-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-hydroxybenzamide, DIMETHYL SULFOXIDE, ... (5 entities in total)
• Functional Keywords: immunity, inflammatory response, transcription repressor, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15176.32

Authors

Kuntz, D.A.,Prive, G.G. (deposition date: 2021-03-10, release date: 2022-03-16, Last modification date: 2023-10-25)

• Primary citation: Mamai, A.,Chau, A.M.,Wilson, B.J.,Watson, I.D.,Joseph, B.B.,Subramanian, P.R.,Morshed, M.M.,Morin, J.A.,Prakesch, M.A.,Lu, T.,Connolly, P.,Kuntz, D.A.,Pomroy, N.C.,Poda, G.,Nguyen, K.,Marcellus, R.,Strathdee, G.,Theriault, B.,Subramaniam, R.,Mohammed, M.,Abibi, A.,Chan, M.,Winston, J.,Kiyota, T.,Undzys, E.,Aman, A.,Austin, N.,Du Jardin, M.,Packman, K.,Phillippar, U.,Attar, R.,Edwards, J.,O'Meara, J.,Uehling, D.E.,Al-Awar, R.,Prive, G.G.,Isaac, M.B.; Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor.; Acs Med.Chem.Lett., 14:199-210, 2023; PubMed: 36793435; DOI: 10.1021/acsmedchemlett.2c00502

Experimental method

X-RAY DIFFRACTION (1.49 Å)