7LZ8
Tubulin-RB3_SLD-TTL in complex with compound 5t
Summary for 7LZ8
Entry DOI | 10.2210/pdb7lz8/pdb |
Descriptor | Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[2-(ethylamino)pyrido[3,2-d]pyrimidin-4-yl]-7-methoxy-3,4-dihydroquinoxalin-2(1H)-one, ... (13 entities in total) |
Functional Keywords | microtubule inhibitor, colchicine, cell cycle, cancer, cell cycle-inhibitor complex, cell cycle/inhibitor |
Biological source | Rattus norvegicus (Rat) More |
Total number of polymer chains | 6 |
Total formula weight | 265242.59 |
Authors | White, S.W.,Yun, M. (deposition date: 2021-03-09, release date: 2021-09-22, Last modification date: 2023-10-18) |
Primary citation | Banerjee, S.,Mahmud, F.,Deng, S.,Ma, L.,Yun, M.K.,Fakayode, S.O.,Arnst, K.E.,Yang, L.,Chen, H.,Wu, Z.,Lukka, P.B.,Parmar, K.,Meibohm, B.,White, S.W.,Wang, Y.,Li, W.,Miller, D.D. X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor. J.Med.Chem., 64:13072-13095, 2021 Cited by PubMed: 34406768DOI: 10.1021/acs.jmedchem.1c01202 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.92 Å) |
Structure validation
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