7LZ4
Crystal structure of A211D mutant of Protein Kinase A RIa subunit, a Carney Complex mutation
Summary for 7LZ4
Entry DOI | 10.2210/pdb7lz4/pdb |
Descriptor | cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE (2 entities in total) |
Functional Keywords | carney complex, cyclic nucleotide binding domain, cyclic amp (camp), protein kinase a (pka), transferase |
Biological source | Bos taurus (Bovine) |
Total number of polymer chains | 8 |
Total formula weight | 248022.89 |
Authors | Del Rio, J.,Wu, J.,Taylor, S.S. (deposition date: 2021-03-08, release date: 2021-05-26, Last modification date: 2023-10-18) |
Primary citation | Jafari, N.,Del Rio, J.,Akimoto, M.,Byun, J.A.,Boulton, S.,Moleschi, K.,Alsayyed, Y.,Swanson, P.,Huang, J.,Martinez Pomier, K.,Lee, C.,Wu, J.,Taylor, S.S.,Melacini, G. Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 34006641DOI: 10.1073/pnas.2024716118 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4.155 Å) |
Structure validation
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