7LZ4

Crystal structure of A211D mutant of Protein Kinase A RIa subunit, a Carney Complex mutation

7LZ4 の概要

• エントリーDOI: 10.2210/pdb7lz4/pdb
• 分子名称: cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE (2 entities in total)
• 機能のキーワード: carney complex, cyclic nucleotide binding domain, cyclic amp (camp), protein kinase a (pka), transferase
• 由来する生物種: Bos taurus (Bovine)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 248022.89

構造登録者

Del Rio, J.,Wu, J.,Taylor, S.S. (登録日: 2021-03-08, 公開日: 2021-05-26, 最終更新日: 2023-10-18)

• 主引用文献: Jafari, N.,Del Rio, J.,Akimoto, M.,Byun, J.A.,Boulton, S.,Moleschi, K.,Alsayyed, Y.,Swanson, P.,Huang, J.,Martinez Pomier, K.,Lee, C.,Wu, J.,Taylor, S.S.,Melacini, G.; Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 34006641; DOI: 10.1073/pnas.2024716118

実験手法

X-RAY DIFFRACTION (4.155 Å)