7LYE

Myotoxin I from Bothrops moojeni co-crystallized with synthetic inhibitor Varespladib (LY315920)

7LYE の概要

• エントリーDOI: 10.2210/pdb7lye/pdb
• 関連するPDBエントリー: 3T0R 6CE2 6PWH
• 分子名称: Basic phospholipase A2 homolog BomoTx, ({3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-indol-4-yl}oxy)acetic acid, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ... (4 entities in total)
• 機能のキーワード: myotoxin i, mjtx-i, pla2-like, toxin
• 由来する生物種: Bothrops moojeni (Lance-headed viper, Caissaca)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 57232.64

構造登録者

Salvador, G.H.M.,Borges, R.J.,Fontes, M.R.M. (登録日: 2021-03-06, 公開日: 2021-05-19, 最終更新日: 2024-10-23)

主引用文献

Salvador, G.H.M.,Borges, R.J.,Lomonte, B.,Lewin, M.R.,Fontes, M.R.M.
The synthetic varespladib molecule is a multi-functional inhibitor for PLA 2 and PLA 2 -like ophidic toxins.
Biochim Biophys Acta Gen Subj, 1865:129913-129913, 2021

PubMed Abstract: The treatment for snakebites is early administration of antivenom, which can be highly effective in inhibiting the systemic effects of snake venoms, but is less effective in the treatment of extra-circulatory and local effects. To complement standard-of-care treatments such as antibody-based antivenoms, natural and synthetic small molecules have been proposed for the inhibition of key venom components such as phospholipase A (PLA) and PLA-like toxins. Varespladib (compound LY315920) is a synthetic molecule developed and clinically tested aiming to block inflammatory cascades of several diseases associated with high PLAs. Recent studies have demonstrated this molecule is able to potently inhibit snake venom catalytic PLA and PLA-like toxins.

PubMed: 33865953
DOI: 10.1016/j.bbagen.2021.129913

実験手法

X-RAY DIFFRACTION (1.758 Å)