7LYC

Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A Lys13 and Lys15 in complex with BARD1 (residues 415-777)

7LYC の概要

• エントリーDOI: 10.2210/pdb7lyc/pdb
• EMDBエントリー: 23590 23591 23592
• 分子名称: Histone H3.1, Histone H4, Histone H2B type 1-J, ... (8 entities in total)
• 機能のキーワード: nucleosome core particle, chromatin, brca1, bard1, dna repair, dna double-strand break, homologous recombination, 53bp1, ard domain, ankyrine repeat domain, tandem brct domain, ubiquitin, structural protein-dna complex, structural protein/dna
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 251070.87

構造登録者

Hu, Q.,Botuyan, M.V.,Zhao, D.,Cui, D.,Mer, E.,Mer, G. (登録日: 2021-03-06, 公開日: 2021-06-16, 最終更新日: 2021-09-01)

• 主引用文献: Hu, Q.,Botuyan, M.V.,Zhao, D.,Cui, G.,Mer, E.,Mer, G.; Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.; Nature, 596:438-443, 2021; PubMed: 34321665; DOI: 10.1038/s41586-021-03716-8

実験手法

ELECTRON MICROSCOPY (2.94 Å)