7LWD
Cryo-EM structure of the wild-type human serotonin transporter complexed with vilazodone, imipramine and 15B8 Fab
Summary for 7LWD
Entry DOI | 10.2210/pdb7lwd/pdb |
EMDB information | 23545 |
Descriptor | Sodium-dependent serotonin transporter, heavy chain antibody fragment, light chain antibody fragment, ... (6 entities in total) |
Functional Keywords | antidepressant, complex, transporter, antibody, transport protein, transport protein-immune system complex, transport protein/immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 86761.87 |
Authors | Yang, D.,Kalenderoglou, I.E.,Gouaux, E.,Coleman, J.A.,Loland, C.J. (deposition date: 2021-03-01, release date: 2021-08-11, Last modification date: 2021-09-01) |
Primary citation | Plenge, P.,Yang, D.,Salomon, K.,Laursen, L.,Kalenderoglou, I.E.,Newman, A.H.,Gouaux, E.,Coleman, J.A.,Loland, C.J. The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter. Nat Commun, 12:5063-5063, 2021 Cited by PubMed: 34417466DOI: 10.1038/s41467-021-25363-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.65 Å) |
Structure validation
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