7LWD

Cryo-EM structure of the wild-type human serotonin transporter complexed with vilazodone, imipramine and 15B8 Fab

7LWD の概要

• エントリーDOI: 10.2210/pdb7lwd/pdb
• EMDBエントリー: 23545
• 分子名称: Sodium-dependent serotonin transporter, heavy chain antibody fragment, light chain antibody fragment, ... (6 entities in total)
• 機能のキーワード: antidepressant, complex, transporter, antibody, transport protein, transport protein-immune system complex, transport protein/immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 86761.87

構造登録者

Yang, D.,Kalenderoglou, I.E.,Gouaux, E.,Coleman, J.A.,Loland, C.J. (登録日: 2021-03-01, 公開日: 2021-08-11, 最終更新日: 2021-09-01)

• 主引用文献: Plenge, P.,Yang, D.,Salomon, K.,Laursen, L.,Kalenderoglou, I.E.,Newman, A.H.,Gouaux, E.,Coleman, J.A.,Loland, C.J.; The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter.; Nat Commun, 12:5063-5063, 2021; PubMed: 34417466; DOI: 10.1038/s41467-021-25363-3

実験手法

ELECTRON MICROSCOPY (3.65 Å)