7LW1

Human phosphofructokinase-1 liver type bound to activator NA-11

Summary for 7LW1

Entry DOI	10.2210/pdb7lw1/pdb
EMDB information	23544
Descriptor	ATP-dependent 6-phosphofructokinase, liver type, N-{(11S)-2-[2-(5-hydroxypent-1-yn-1-yl)phenyl]-4H,10H-pyrazolo[5,1-c][1,4]benzoxazepin-7-yl}acetamide, 1,6-di-O-phosphono-beta-D-fructofuranose, ... (5 entities in total)
Functional Keywords	glycolysis, phosphofructokinase, liver type, activated, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	346197.14
Authors	Lynch, E.M.,Kollman, J.M.,Webb, B. (deposition date: 2021-02-27, release date: 2022-01-26, Last modification date: 2024-05-29)
Primary citation	Amara, N.,Cooper, M.P.,Voronkova, M.A.,Webb, B.A.,Lynch, E.M.,Kollman, J.M.,Ma, T.,Yu, K.,Lai, Z.,Sangaraju, D.,Kayagaki, N.,Newton, K.,Bogyo, M.,Staben, S.T.,Dixit, V.M. Selective activation of PFKL suppresses the phagocytic oxidative burst. Cell, 184:4480-4494.e15, 2021 Cited by PubMed: 34320407 DOI: 10.1016/j.cell.2021.07.004 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.9 Å)

Structure validation