7LVJ

CASP8 isoform G DED domain

7LVJ の概要

• エントリーDOI: 10.2210/pdb7lvj/pdb
• 関連するPDBエントリー: 7LVM
• 分子名称: Isoform 9 of Caspase-8 (2 entities in total)
• 機能のキーワード: casp8g, casp8, gene id: 841, casp8g ded, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30014.52

構造登録者

Weichert, K.,Lu, F.,Kodandapani, L.,Sauder, J.M. (登録日: 2021-02-25, 公開日: 2022-03-02, 最終更新日: 2024-04-03)

主引用文献

Ansalone, C.,Ainsworth, R.I.,Nygaard, G.,Ai, R.,Prideaux, E.B.,Hammaker, D.,Perumal, N.B.,Weichert, K.,Tung, F.,Kodandapani, L.,Sauder, J.M.,Mertsching, E.C.,Benschop, R.J.,Boyle, D.L.,Wang, W.,Firestein, G.S.
Caspase-8 Variant G Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Aggressive Behavior.
ACR Open Rheumatol, 4:288-299, 2022

PubMed Abstract: Fibroblast-like synoviocytes (FLS) play a pivotal role in rheumatoid arthritis (RA) by contributing to synovial inflammation and progressive joint damage. An imprinted epigenetic state is associated with the FLS aggressive phenotype. We identified CASP8 (encoding for caspase-8) as a differentially marked gene and evaluated its pathogenic role in RA FLSs.

PubMed: 34963199
DOI: 10.1002/acr2.11384

実験手法

X-RAY DIFFRACTION (1.5 Å)