7LUE

Prefusion RSV F glycoprotein bound by neutralizing site V-directed antibody ADI-14442

7LUE の概要

• エントリーDOI: 10.2210/pdb7lue/pdb
• EMDBエントリー: 23521
• 分子名称: Fusion glycoprotein F0, Heavy chain of human antibody Fab ADI-14442, Light chain of human antibody Fab ADI-14442 (3 entities in total)
• 機能のキーワード: fusion, immunoglobulin, public clonotype, convergent recognition, viral protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Respiratory syncytial virus A2; 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 327117.33

構造登録者

Gilman, M.S.A.,McLellan, J.S. (登録日: 2021-02-22, 公開日: 2021-06-16)

• 主引用文献: Mukhamedova, M.,Wrapp, D.,Shen, C.H.,Gilman, M.S.A.,Ruckwardt, T.J.,Schramm, C.A.,Ault, L.,Chang, L.,Derrien-Colemyn, A.,Lucas, S.A.M.,Ransier, A.,Darko, S.,Phung, E.,Wang, L.,Zhang, Y.,Rush, S.A.,Madan, B.,Stewart-Jones, G.B.E.,Costner, P.J.,Holman, L.A.,Hickman, S.P.,Berkowitz, N.M.,Doria-Rose, N.A.,Morabito, K.M.,DeKosky, B.J.,Gaudinski, M.R.,Chen, G.L.,Crank, M.C.,Misasi, J.,Sullivan, N.J.,Douek, D.C.,Kwong, P.D.,Graham, B.S.,McLellan, J.S.,Mascola, J.R.; Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses.; Immunity, 54:769-780.e6, 2021; PubMed: 33823129; DOI: 10.1016/j.immuni.2021.03.004

実験手法

ELECTRON MICROSCOPY (2.9 Å)