7LUA
Cryo-EM structure of DH898.1 Fab-dimer bound near the CD4 binding site of HIV-1 Env CH848 SOSIP trimer
Summary for 7LUA
Entry DOI | 10.2210/pdb7lua/pdb |
Related | 6XRJ 7L02 7L06 7L09 7L6M 7L6O 7LU9 |
EMDB information | 23518 23519 |
Descriptor | CH848 SOSIP gp120, Env polyprotein, DH898.1 light chain, ... (9 entities in total) |
Functional Keywords | fab-dimerized, glycan-reactive, antibodies, hiv-1, dh898.1, fab-dimer, glycan-reactive neutralizing antibody, macaque hiv-1 vaccine-induced, b cell lineage, viral protein-immune system complex, viral protein/immune system |
Biological source | Human immunodeficiency virus 1 (HIV-1) More |
Total number of polymer chains | 10 |
Total formula weight | 327768.38 |
Authors | Manne, K.,Edwards, R.J.,Acharya, P. (deposition date: 2021-02-21, release date: 2021-03-17, Last modification date: 2021-06-09) |
Primary citation | Williams, W.B.,Meyerhoff, R.R.,Edwards, R.J.,Li, H.,Manne, K.,Nicely, N.I.,Henderson, R.,Zhou, Y.,Janowska, K.,Mansouri, K.,Gobeil, S.,Evangelous, T.,Hora, B.,Berry, M.,Abuahmad, A.Y.,Sprenz, J.,Deyton, M.,Stalls, V.,Kopp, M.,Hsu, A.L.,Borgnia, M.J.,Stewart-Jones, G.B.E.,Lee, M.S.,Bronkema, N.,Moody, M.A.,Wiehe, K.,Bradley, T.,Alam, S.M.,Parks, R.J.,Foulger, A.,Oguin, T.,Sempowski, G.D.,Bonsignori, M.,LaBranche, C.C.,Montefiori, D.C.,Seaman, M.,Santra, S.,Perfect, J.,Francica, J.R.,Lynn, G.M.,Aussedat, B.,Walkowicz, W.E.,Laga, R.,Kelsoe, G.,Saunders, K.O.,Fera, D.,Kwong, P.D.,Seder, R.A.,Bartesaghi, A.,Shaw, G.M.,Acharya, P.,Haynes, B.F. Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies. Cell, 184:2955-, 2021 Cited by PubMed: 34019795DOI: 10.1016/j.cell.2021.04.042 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.7 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)