7LUA
Cryo-EM structure of DH898.1 Fab-dimer bound near the CD4 binding site of HIV-1 Env CH848 SOSIP trimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E (a, c, e) | CH848 SOSIP gp120 | polymer | 466 | 52061.9 | 3 | UniProt (A0A1W6IPB2) Pfam (PF00516) | Human immunodeficiency virus 1 (HIV-1) | Envelope glycoprotein gp120 |
| 2 | B, D, F (b, d, f) | Env polyprotein | polymer | 146 | 16578.8 | 3 | UniProt (A0A6H1VEB8) Pfam (PF00517) UniProt (by SIFTS) (A0A6H1V945) | Simian-Human immunodeficiency virus | Envelope glycoprotein gp160,Glycoprotein 120,Surface protein gp120,Transmembrane protein gp41 |
| 3 | G, J (g, j) | DH898.1 light chain | polymer | 218 | 23553.3 | 2 | Homo sapiens (Human) | ||
| 4 | H, I (h, i) | DH898.1 heavy chain | polymer | 219 | 23596.6 | 2 | Homo sapiens (Human) | ||
| 5 | BA, DA, EA, GA, HA... (R, T, U, W, X...) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 26 | In PDB GlyTouCan (G15407YE) | |||
| 6 | AA, FA, IA, L, NA... (Q, V, Y, B, n...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 9 | In PDB GlyTouCan (G42666HT) | |||
| 7 | CA, N, PA, X (S, D, p, N) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 4 | In PDB GlyTouCan (G22768VO) | |||
| 8 | W (M) | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G34442SS) | |||
| 9 | AB, BB, CB, DB, EB... (a, b, c, d, e...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 17 | Chemie (NAG) |
Sequence modifications
a, c, e: 34 - 506 (UniProt: A0A1W6IPB2)
b, d, f: 507 - 652 (UniProt: A0A6H1VEB8)
| PDB | External Database | Details |
|---|---|---|
| Ala 31 | - | expression tag |
| Glu 32 | - | expression tag |
| Asn 33 | - | expression tag |
| Cys 201 | Val 189 | conflict |
| Cys 433 | Ala 417 | conflict |
| Lys 490 | Glu 474 | conflict |
| Glu 492 | Gln 476 | conflict |
| Val 496 | Ile 480 | conflict |
| Arg 500 | Gly 484 | conflict |
| Cys 501 | Ala 485 | conflict |
| Gly 506 | Glu 491 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Pro 547 | Ile 556 | conflict |
| Cys 593 | Thr 602 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 300221.9 | |
| Branched | Number of molecules | 40 |
| Total formula weight | 23786.0 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 3760.5 | |
| All* | Total formula weight | 327768.4 |
