7LU7

Human TDO (hTDO) in complex with NLG919 analog

This is a non-PDB format compatible entry.

Summary for 7LU7

• Entry DOI: 10.2210/pdb7lu7/pdb
• Descriptor: Tryptophan 2,3-dioxygenase, PROTOPORPHYRIN IX CONTAINING FE, alpha-methyl-L-tryptophan, ... (5 entities in total)
• Functional Keywords: human tdo, human tdo2, htdo, htdo2, nlg919, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 185198.62

Authors

Yeh, S.-R. (deposition date: 2021-02-21, release date: 2022-08-24, Last modification date: 2024-08-28)

• Primary citation: Geeraerts, Z.,Ishigami, I.,Lewis-Ballester, A.,Pham, K.N.,Kozlova, A.,Mathieu, C.,Frederick, R.,Yeh, S.R.; Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.; J.Med.Chem., 2024; PubMed: 39106326; DOI: 10.1021/acs.jmedchem.4c01360

Experimental method

X-RAY DIFFRACTION (2.3 Å)