7LU7

Human TDO (hTDO) in complex with NLG919 analog

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
AAA	0005515	molecular_function	protein binding
AAA	0005829	cellular_component	cytosol
AAA	0006568	biological_process	tryptophan metabolic process
AAA	0006569	biological_process	tryptophan catabolic process
AAA	0016597	molecular_function	amino acid binding
AAA	0019441	biological_process	tryptophan catabolic process to kynurenine
AAA	0019442	biological_process	tryptophan catabolic process to acetyl-CoA
AAA	0019825	molecular_function	oxygen binding
AAA	0020037	molecular_function	heme binding
AAA	0042802	molecular_function	identical protein binding
AAA	0046872	molecular_function	metal ion binding
AAA	0051213	molecular_function	dioxygenase activity
AAA	0051289	biological_process	protein homotetramerization
AAA	1904842	biological_process	response to nitroglycerin
BBB	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
BBB	0005515	molecular_function	protein binding
BBB	0005829	cellular_component	cytosol
BBB	0006568	biological_process	tryptophan metabolic process
BBB	0006569	biological_process	tryptophan catabolic process
BBB	0016597	molecular_function	amino acid binding
BBB	0019441	biological_process	tryptophan catabolic process to kynurenine
BBB	0019442	biological_process	tryptophan catabolic process to acetyl-CoA
BBB	0019825	molecular_function	oxygen binding
BBB	0020037	molecular_function	heme binding
BBB	0042802	molecular_function	identical protein binding
BBB	0046872	molecular_function	metal ion binding
BBB	0051213	molecular_function	dioxygenase activity
BBB	0051289	biological_process	protein homotetramerization
BBB	1904842	biological_process	response to nitroglycerin
CCC	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
CCC	0005515	molecular_function	protein binding
CCC	0005829	cellular_component	cytosol
CCC	0006568	biological_process	tryptophan metabolic process
CCC	0006569	biological_process	tryptophan catabolic process
CCC	0016597	molecular_function	amino acid binding
CCC	0019441	biological_process	tryptophan catabolic process to kynurenine
CCC	0019442	biological_process	tryptophan catabolic process to acetyl-CoA
CCC	0019825	molecular_function	oxygen binding
CCC	0020037	molecular_function	heme binding
CCC	0042802	molecular_function	identical protein binding
CCC	0046872	molecular_function	metal ion binding
CCC	0051213	molecular_function	dioxygenase activity
CCC	0051289	biological_process	protein homotetramerization
CCC	1904842	biological_process	response to nitroglycerin
DDD	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
DDD	0005515	molecular_function	protein binding
DDD	0005829	cellular_component	cytosol
DDD	0006568	biological_process	tryptophan metabolic process
DDD	0006569	biological_process	tryptophan catabolic process
DDD	0016597	molecular_function	amino acid binding
DDD	0019441	biological_process	tryptophan catabolic process to kynurenine
DDD	0019442	biological_process	tryptophan catabolic process to acetyl-CoA
DDD	0019825	molecular_function	oxygen binding
DDD	0020037	molecular_function	heme binding
DDD	0042802	molecular_function	identical protein binding
DDD	0046872	molecular_function	metal ion binding
DDD	0051213	molecular_function	dioxygenase activity
DDD	0051289	biological_process	protein homotetramerization
DDD	1904842	biological_process	response to nitroglycerin

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03020, ECO:0000269|PubMed:27762317, ECO:0007744|PDB:5TI9

Chain	Residue	Details
AAA	PHE72
DDD	PHE72
DDD	ARG144
DDD	THR342
AAA	ARG144
AAA	THR342
BBB	PHE72
BBB	ARG144
BBB	THR342
CCC	PHE72
CCC	ARG144
CCC	THR342

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: axial binding residue => ECO:0000255|HAMAP-Rule:MF_03020, ECO:0000269|PubMed:27762317, ECO:0007744|PDB:5TI9

Chain	Residue	Details
AAA	HIS328
BBB	HIS328
CCC	HIS328
DDD	HIS328

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