7LU7

Human TDO (hTDO) in complex with NLG919 analog

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0004833	molecular_function	L-tryptophan 2,3-dioxygenase activity
AAA	0005515	molecular_function	protein binding
AAA	0005829	cellular_component	cytosol
AAA	0006568	biological_process	L-tryptophan metabolic process
AAA	0006569	biological_process	L-tryptophan catabolic process
AAA	0016491	molecular_function	oxidoreductase activity
AAA	0016597	molecular_function	amino acid binding
AAA	0019441	biological_process	obsolete L-tryptophan catabolic process to L-kynurenine
AAA	0019442	biological_process	obsolete L-tryptophan catabolic process to acetyl-CoA
AAA	0019825	molecular_function	oxygen binding
AAA	0020037	molecular_function	heme binding
AAA	0042802	molecular_function	identical protein binding
AAA	0045471	biological_process	response to ethanol
AAA	0046872	molecular_function	metal ion binding
AAA	0051213	molecular_function	dioxygenase activity
AAA	0051289	biological_process	protein homotetramerization
AAA	0051414	biological_process	response to cortisol
AAA	1904842	biological_process	response to nitroglycerin
BBB	0004833	molecular_function	L-tryptophan 2,3-dioxygenase activity
BBB	0005515	molecular_function	protein binding
BBB	0005829	cellular_component	cytosol
BBB	0006568	biological_process	L-tryptophan metabolic process
BBB	0006569	biological_process	L-tryptophan catabolic process
BBB	0016491	molecular_function	oxidoreductase activity
BBB	0016597	molecular_function	amino acid binding
BBB	0019441	biological_process	obsolete L-tryptophan catabolic process to L-kynurenine
BBB	0019442	biological_process	obsolete L-tryptophan catabolic process to acetyl-CoA
BBB	0019825	molecular_function	oxygen binding
BBB	0020037	molecular_function	heme binding
BBB	0042802	molecular_function	identical protein binding
BBB	0045471	biological_process	response to ethanol
BBB	0046872	molecular_function	metal ion binding
BBB	0051213	molecular_function	dioxygenase activity
BBB	0051289	biological_process	protein homotetramerization
BBB	0051414	biological_process	response to cortisol
BBB	1904842	biological_process	response to nitroglycerin
CCC	0004833	molecular_function	L-tryptophan 2,3-dioxygenase activity
CCC	0005515	molecular_function	protein binding
CCC	0005829	cellular_component	cytosol
CCC	0006568	biological_process	L-tryptophan metabolic process
CCC	0006569	biological_process	L-tryptophan catabolic process
CCC	0016491	molecular_function	oxidoreductase activity
CCC	0016597	molecular_function	amino acid binding
CCC	0019441	biological_process	obsolete L-tryptophan catabolic process to L-kynurenine
CCC	0019442	biological_process	obsolete L-tryptophan catabolic process to acetyl-CoA
CCC	0019825	molecular_function	oxygen binding
CCC	0020037	molecular_function	heme binding
CCC	0042802	molecular_function	identical protein binding
CCC	0045471	biological_process	response to ethanol
CCC	0046872	molecular_function	metal ion binding
CCC	0051213	molecular_function	dioxygenase activity
CCC	0051289	biological_process	protein homotetramerization
CCC	0051414	biological_process	response to cortisol
CCC	1904842	biological_process	response to nitroglycerin
DDD	0004833	molecular_function	L-tryptophan 2,3-dioxygenase activity
DDD	0005515	molecular_function	protein binding
DDD	0005829	cellular_component	cytosol
DDD	0006568	biological_process	L-tryptophan metabolic process
DDD	0006569	biological_process	L-tryptophan catabolic process
DDD	0016491	molecular_function	oxidoreductase activity
DDD	0016597	molecular_function	amino acid binding
DDD	0019441	biological_process	obsolete L-tryptophan catabolic process to L-kynurenine
DDD	0019442	biological_process	obsolete L-tryptophan catabolic process to acetyl-CoA
DDD	0019825	molecular_function	oxygen binding
DDD	0020037	molecular_function	heme binding
DDD	0042802	molecular_function	identical protein binding
DDD	0045471	biological_process	response to ethanol
DDD	0046872	molecular_function	metal ion binding
DDD	0051213	molecular_function	dioxygenase activity
DDD	0051289	biological_process	protein homotetramerization
DDD	0051414	biological_process	response to cortisol
DDD	1904842	biological_process	response to nitroglycerin

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03020","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27762317","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TI9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"HAMAP-Rule","id":"MF_03020","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27762317","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TI9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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