7LU5

SAMHD1(113-626) H206R D207N R366H

Summary for 7LU5

• Entry DOI: 10.2210/pdb7lu5/pdb
• Related: 7LTT
• Descriptor: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE (2 entities in total)
• Functional Keywords: dntpase, tetramer, mutant, cancer, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 16
• Total formula weight: 1006432.80

Authors

Temple, J.T.,Bowen, N.E. (deposition date: 2021-02-20, release date: 2021-11-24, Last modification date: 2023-10-18)

• Primary citation: Bowen, N.E.,Temple, J.,Shepard, C.,Oo, A.,Arizaga, F.,Kapoor-Vazirani, P.,Persaud, M.,Yu, C.H.,Kim, D.H.,Schinazi, R.F.,Ivanov, D.N.,Diaz-Griffero, F.,Yu, D.S.,Xiong, Y.,Kim, B.; Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins.; J.Biol.Chem., 297:101170-101170, 2021; PubMed: 34492268; DOI: 10.1016/j.jbc.2021.101170

Experimental method

X-RAY DIFFRACTION (3.57 Å)