7LTT

SAMHD1(113-626) H206R D207N R366C

Summary for 7LTT

Entry DOI	10.2210/pdb7ltt/pdb
Descriptor	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	dntpase, tetramer, mutant, cancer, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	251565.42
Authors	Temple, J.T.,Bowen, N.E. (deposition date: 2021-02-20, release date: 2021-11-24, Last modification date: 2023-10-18)
Primary citation	Bowen, N.E.,Temple, J.,Shepard, C.,Oo, A.,Arizaga, F.,Kapoor-Vazirani, P.,Persaud, M.,Yu, C.H.,Kim, D.H.,Schinazi, R.F.,Ivanov, D.N.,Diaz-Griffero, F.,Yu, D.S.,Xiong, Y.,Kim, B. Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins. J.Biol.Chem., 297:101170-101170, 2021 Cited by PubMed: 34492268 DOI: 10.1016/j.jbc.2021.101170 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation