7LTL

STRUCTURE OF HUMAN HDAC2 IN COMPLEX WITH AN INHIBITOR LACKING A ZINC BINDING GROUP (COMPOUND 19)

Summary for 7LTL

Entry DOI	10.2210/pdb7ltl/pdb
Descriptor	Histone deacetylase 2, ZINC ION, SULFATE ION, ... (8 entities in total)
Functional Keywords	histone deacetylase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	133124.11
Authors	Klein, D.J.,Beshore, D.C. (deposition date: 2021-02-19, release date: 2021-05-05, Last modification date: 2024-03-06)
Primary citation	Beshore, D.C.,Adam, G.C.,Barnard, R.J.O.,Burlein, C.,Gallicchio, S.N.,Holloway, M.K.,Krosky, D.,Lemaire, W.,Myers, R.W.,Patel, S.,Plotkin, M.A.,Powell, D.A.,Rada, V.,Cox, C.D.,Coleman, P.J.,Klein, D.J.,Wolkenberg, S.E. Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction. Acs Med.Chem.Lett., 12:540-547, 2021 Cited by PubMed: 33854701 DOI: 10.1021/acsmedchemlett.1c00074 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.49 Å)

Structure validation