7LS0

Structure of the Human ALK GRD bound to AUG

7LS0 の概要

• エントリーDOI: 10.2210/pdb7ls0/pdb
• 分子名称: ALK tyrosine kinase receptor fused with ALK and LTK ligand 2, CITRIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: glycine rich domain, neuroblastoma, cancer, oncogene, signaling protein, transferase, transferase-transferase activator complex, transferase/transferase activator
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 190104.30

構造登録者

Stayrook, S.,Li, T.,Klein, D.E. (登録日: 2021-02-17, 公開日: 2021-11-24, 最終更新日: 2023-10-18)

• 主引用文献: Li, T.,Stayrook, S.E.,Tsutsui, Y.,Zhang, J.,Wang, Y.,Li, H.,Proffitt, A.,Krimmer, S.G.,Ahmed, M.,Belliveau, O.,Walker, I.X.,Mudumbi, K.C.,Suzuki, Y.,Lax, I.,Alvarado, D.,Lemmon, M.A.,Schlessinger, J.,Klein, D.E.; Structural basis for ligand reception by anaplastic lymphoma kinase.; Nature, 600:148-152, 2021; PubMed: 34819665; DOI: 10.1038/s41586-021-04141-7

実験手法

X-RAY DIFFRACTION (3.05 Å)