7LRQ

Crystal structure of human SFPQ/NONO heterodimer, conserved DBHS region

Summary for 7LRQ

Entry DOI	10.2210/pdb7lrq/pdb
Descriptor	Splicing factor, proline- and glutamine-rich, Non-POU domain-containing octamer-binding protein, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	dbhs protein, nuclear protein, nucleic acid binding, paraspeckle formation, rna binding protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	60159.50
Authors	Marshall, A.C.,Bond, C.S.,Mohnen, I. (deposition date: 2021-02-17, release date: 2021-05-12, Last modification date: 2023-10-25)
Primary citation	Lee, P.W.,Marshall, A.C.,Knott, G.J.,Kobelke, S.,Martelotto, L.,Cho, E.,McMillan, P.J.,Lee, M.,Bond, C.S.,Fox, A.H. Paraspeckle subnuclear bodies depend on dynamic heterodimerisation of DBHS RNA-binding proteins via their structured domains. J.Biol.Chem., 298:102563-102563, 2022 Cited by PubMed: 36209820 DOI: 10.1016/j.jbc.2022.102563 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation