7LPE
Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an open state, class 1
Summary for 7LPE
Entry DOI | 10.2210/pdb7lpe/pdb |
EMDB information | 23479 |
Descriptor | Transient receptor potential cation channel subfamily V member 1, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, ... (4 entities in total) |
Functional Keywords | heat sensing ion channel, membrane protein |
Biological source | Rattus norvegicus (Rat) |
Total number of polymer chains | 4 |
Total formula weight | 402012.97 |
Authors | Kwon, D.H.,Zhang, F.,Suo, Y.,Lee, S.-Y. (deposition date: 2021-02-11, release date: 2021-07-28, Last modification date: 2024-10-16) |
Primary citation | Kwon, D.H.,Zhang, F.,Suo, Y.,Bouvette, J.,Borgnia, M.J.,Lee, S.Y. Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28:554-563, 2021 Cited by PubMed: 34239123DOI: 10.1038/s41594-021-00616-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.72 Å) |
Structure validation
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