7LON

Ornithine Aminotransferase (OAT) cocrystallized with its inactivator - (1S,3S)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid

7LON の概要

• エントリーDOI: 10.2210/pdb7lon/pdb
• 分子名称: Ornithine aminotransferase, mitochondrial, THREONINE, (1R,3S,4R)-3-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-4-methylcyclohexane-1-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: ornithine aminotransferase, oat, aminotransferase, inactivator, inhibitor, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 136103.38

構造登録者

Butrin, A.,Zhu, W.,Liu, D.,Silverman, R. (登録日: 2021-02-10, 公開日: 2021-08-25, 最終更新日: 2023-10-18)

• 主引用文献: Zhu, W.,Doubleday, P.F.,Butrin, A.,Weerawarna, P.M.,Melani, R.D.,Catlin, D.S.,Dwight, T.A.,Liu, D.,Kelleher, N.L.,Silverman, R.B.; Remarkable and Unexpected Mechanism for ( S )-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase.; J.Am.Chem.Soc., 143:8193-8207, 2021; PubMed: 34014654; DOI: 10.1021/jacs.1c03572

実験手法

X-RAY DIFFRACTION (1.95 Å)