7LO6

Structure of CD4 mimetic BNM-III-170 in complex with BG505 SOSIP.664 HIV-1 Env trimer and 17b Fab

Summary for 7LO6

• Entry DOI: 10.2210/pdb7lo6/pdb
• EMDB information: 23462
• Descriptor: Envelope glycoprotein BG505 SOSIP.664 gp120, ~{N}'-[(1~{R},2~{R})-2-(carbamimidamidomethyl)-5-(methylaminomethyl)-2,3-dihydro-1~{H}-inden-1-yl]-~{N}-(4-chloranyl-3-fluoranyl-phenyl)ethanediamide, HIV-1 Envelope Glycoprotein BG505 SOSIP.664 gp41, ... (10 entities in total)
• Functional Keywords: cd4m, fusion, hiv-1, entry, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 12
• Total formula weight: 373980.74

Authors

Jette, C.A.,Bjorkman, P.J. (deposition date: 2021-02-09, release date: 2021-04-14)

• Primary citation: Jette, C.A.,Barnes, C.O.,Kirk, S.M.,Melillo, B.,Smith III, A.B.,Bjorkman, P.J.; Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation.; Nat Commun, 12:1950-1950, 2021; PubMed: 33782388; DOI: 10.1038/s41467-021-21816-x

Experimental method

ELECTRON MICROSCOPY (3.9 Å)