7LNH

S-adenosylmethionine synthetase co-crystallized with UppNHp

7LNH の概要

• エントリーDOI: 10.2210/pdb7lnh/pdb
• 分子名称: S-adenosylmethionine synthase isoform type-2, (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl-methyl-$l^{3}-sulfanyl]butanoic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: s-adenosylmethionine synthetase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 88254.11

構造登録者

Tan, L.L.,Jackson, C.J. (登録日: 2021-02-07, 公開日: 2022-03-02, 最終更新日: 2023-10-18)

• 主引用文献: Gade, M.,Tan, L.L.,Damry, A.M.,Sandhu, M.,Brock, J.S.,Delaney, A.,Villar-Briones, A.,Jackson, C.J.,Laurino, P.; Substrate Dynamics Contribute to Enzymatic Specificity in Human and Bacterial Methionine Adenosyltransferases.; Jacs Au, 1:2349-2360, 2021; PubMed: 34977903; DOI: 10.1021/jacsau.1c00464

実験手法

X-RAY DIFFRACTION (2.5 Å)