7LMY
Cryo-EM structure of human p97 in complex with NMS-873 in the presence of ATP, Npl4/Ufd1, and Ub6
Summary for 7LMY
Entry DOI | 10.2210/pdb7lmy/pdb |
EMDB information | 23442 23443 23444 23445 23446 23447 23448 23449 23450 23451 23452 23453 23454 23455 23456 23457 23458 |
Descriptor | Transitional endoplasmic reticulum ATPase, ADENOSINE-5'-TRIPHOSPHATE, 3-[3-cyclopentylsulfanyl-5-[[3-methyl-4-(4-methylsulfonylphenyl)phenoxy]methyl]-1,2,4-triazol-4-yl]pyridine, ... (4 entities in total) |
Functional Keywords | p97, nms-873, single-particle cryo-em, translocation, allosteric inhibition, translocase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 6 |
Total formula weight | 546464.94 |
Authors | |
Primary citation | Pan, M.,Yu, Y.,Ai, H.,Zheng, Q.,Xie, Y.,Liu, L.,Zhao, M. Mechanistic insight into substrate processing and allosteric inhibition of human p97. Nat.Struct.Mol.Biol., 28:614-625, 2021 Cited by PubMed: 34262183DOI: 10.1038/s41594-021-00617-2 PDB entries with the same primary citation |
Experimental method |
Structure validation
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