7LMO

Structure of full-length human lambda-6A light chain JTO in complex with stabilizer 34 [3-(2-(7-(diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl)ethyl)-7-(1H-imidazole-5-carbonyl)-1,3,7-triazaspiro[4.4]nonane-2,4-dione]

Summary for 7LMO

• Entry DOI: 10.2210/pdb7lmo/pdb
• Descriptor: JTO light chain, PHOSPHATE ION, (5~{R})-3-[2-[7-(diethylamino)-4-methyl-2-oxidanylidene-chromen-3-yl]ethyl]-7-(1~{H}-imidazol-4-ylcarbonyl)-1,3,7-triazaspiro[4.4]nonane-2,4-dione, ... (4 entities in total)
• Functional Keywords: amyloidosis, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 47119.58

Authors

Yan, N.L.,Wilson, I.A.,Kelly, J.W. (deposition date: 2021-02-05, release date: 2021-05-19, Last modification date: 2023-10-18)

• Primary citation: Yan, N.L.,Santos-Martins, D.,Nair, R.,Chu, A.,Wilson, I.A.,Johnson, K.A.,Forli, S.,Morgan, G.J.,Petrassi, H.M.,Kelly, J.W.; Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.; J.Med.Chem., 64:6273-6299, 2021; PubMed: 33939422; DOI: 10.1021/acs.jmedchem.1c00339

Experimental method